Methadone

Definition

Methadone is a synthetic opioid used primarily for pain management and as part of medication-assisted treatment (MAT) for opioid use disorder. It works by binding to the same receptors in the brain as other opioids, reducing withdrawal symptoms and cravings.

5 Must Know Facts For Your Next Test

1. Methadone has a long half-life, which allows for once-daily dosing in addiction treatment.
2. It can cause respiratory depression, especially when taken in high doses or combined with other CNS depressants.
3. Methadone is metabolized by the liver and has potential interactions with various medications that affect liver enzymes.
4. As an opioid agonist, methadone can be addictive, requiring careful monitoring during treatment.
5. It is available in several forms including tablets, liquid solutions, and injectable formulations.

Review Questions

• What are the primary medical uses of methadone?
• How does methadone help in treating opioid use disorder?
• What are some potential risks associated with methadone therapy?

Related terms

Naloxone:

An opioid antagonist used to reverse opioid overdoses.

Buprenorphine:

A partial opioid agonist used for pain relief and to treat opioid dependence.

Naltrexone:

An opioid antagonist used in the management of alcohol dependence and prevention of relapse in opioid addiction after detoxification.