Mast cell stabilizers

Definition

Mast cell stabilizers are medications used to prevent the release of histamine and other inflammatory mediators from mast cells, thus reducing allergic reactions and inflammation. They are commonly used for managing asthma and allergic rhinitis.

5 Must Know Facts For Your Next Test

1. Mast cell stabilizers work by inhibiting the degranulation of mast cells, thereby preventing the release of histamine.
2. Commonly prescribed mast cell stabilizers include cromolyn sodium and nedocromil.
3. These medications are often used as a prophylactic treatment for asthma rather than for acute symptom relief.
4. Mast cell stabilizers can take several weeks to achieve their full therapeutic effect, requiring consistent use.
5. They are generally well-tolerated with minimal side effects, making them suitable for long-term use.

Review Questions

• What is the primary mechanism of action for mast cell stabilizers?
• Name two commonly prescribed mast cell stabilizers.
• Why are mast cell stabilizers not typically used for acute asthma attacks?

Related terms

Xanthines:

A class of drugs that includes theophylline, which is used to treat respiratory diseases like asthma by relaxing bronchial muscles.

Leukotriene Modifiers:

Medications that block leukotrienes to reduce inflammation and constriction in the airways, often used in asthma management.

Histamine:

A compound released by mast cells during allergic reactions that causes symptoms like swelling, itching, and bronchoconstriction.