Loop diuretics

Definition

Loop diuretics are a class of medications that act on the ascending limb of the loop of Henle in the kidney to inhibit sodium and chloride reabsorption. They are commonly used to treat conditions like heart failure, hypertension, and edema.

5 Must Know Facts For Your Next Test

1. Loop diuretics increase urine output by preventing sodium and chloride reabsorption in the kidneys.
2. Commonly prescribed loop diuretics include furosemide, bumetanide, and torsemide.
3. They can cause electrolyte imbalances such as hypokalemia (low potassium levels) and hyponatremia (low sodium levels).
4. Loop diuretics are often used in acute settings due to their rapid onset of action.
5. Patients taking loop diuretics should be monitored for signs of dehydration and renal function.

Review Questions

• What is the primary site of action for loop diuretics in the kidney?
• Name three commonly prescribed loop diuretics.
• What are some potential electrolyte imbalances caused by loop diuretics?

Related terms

Thiazide Diuretics:

A class of diuretics that act on the distal convoluted tubule to prevent sodium reabsorption.

Potassium-Sparing Diuretics:

Diuretic drugs that help retain potassium while promoting sodium excretion.

Heart Failure:

A condition in which the heart cannot pump enough blood to meet the body's needs, often treated with medications including loop diuretics.