Telomerase
from class: Microbiology Definition Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, called telomeres. This helps protect genetic information during DNA replication.
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Predict what's on your test 5 Must Know Facts For Your Next Test Telomerase is most active in stem cells and germ cells but has low activity in most somatic cells. The enzyme uses an RNA template to extend the telomeres, which prevents chromosome degradation. Telomerase activity is crucial for maintaining chromosomal stability and integrity. Dysregulation of telomerase can lead to cancerous growth due to unchecked cell division. Inhibition of telomerase is a potential target for cancer therapy. Review Questions What role does telomerase play in DNA replication? Why is telomerase activity low in most somatic cells? How could dysregulation of telomerase contribute to cancer development? "Telomerase" also found in:
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