Intermediate filaments

Definition

Intermediate filaments are cytoskeletal components found in eukaryotic cells that provide structural support and mechanical strength. They are composed of various proteins, depending on the cell type.

5 Must Know Facts For Your Next Test

1. Intermediate filaments have a diameter of about 10 nanometers, which is intermediate between microfilaments and microtubules.
2. They are more stable than other cytoskeletal elements and do not undergo rapid assembly and disassembly.
3. Types of intermediate filament proteins include keratins, vimentin, and neurofilaments.
4. They play a crucial role in maintaining cell shape and integrity by anchoring organelles and forming a network throughout the cytoplasm.
5. Mutations in intermediate filament genes can lead to diseases such as epidermolysis bullosa simplex and certain types of muscular dystrophy.

Review Questions

• What is the primary function of intermediate filaments?
• Name two proteins that make up intermediate filaments.
• How do intermediate filaments differ from microfilaments and microtubules in terms of stability?

Related terms

Microtubules:

Cylindrical structures made of tubulin that are involved in cell division, intracellular transport, and structural support.

Microfilaments:

Thin strands composed primarily of actin that aid in cell movement, shape, and division.

Cytoskeleton:

A network of protein fibers within a cell that provides structure, shape, and enables cellular motion.