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Glyphosate

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Toxicology

Definition

Glyphosate is a broad-spectrum systemic herbicide commonly used to kill weeds, especially annual broadleaf weeds and grasses that compete with crops. It is the active ingredient in many herbicides, including the popular Roundup brand, and works by inhibiting a specific enzyme pathway in plants and some microorganisms, making it significant in agricultural practices.

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5 Must Know Facts For Your Next Test

  1. Glyphosate was discovered to be an herbicide by Monsanto chemist John E. Franz in 1970 and has since become one of the most widely used herbicides in the world.
  2. The herbicide works by blocking a specific enzyme pathway (the shikimic acid pathway) that is essential for plant growth and development, which humans and animals do not possess.
  3. Concerns about glyphosate have arisen due to its potential carcinogenic effects, leading to various legal actions against companies like Monsanto (now Bayer).
  4. Glyphosate-resistant crops, such as soybeans and corn, were developed to withstand applications of glyphosate, allowing farmers to control weeds without harming their crops.
  5. The use of glyphosate has sparked debates over environmental sustainability and biodiversity, as its widespread application can lead to herbicide-resistant weed populations.

Review Questions

  • How does glyphosate function as an herbicide, and what makes it effective against certain types of plants?
    • Glyphosate functions by inhibiting the shikimic acid pathway, an essential metabolic route found in plants and some microorganisms but absent in animals. This pathway is crucial for the synthesis of certain amino acids needed for plant growth. As a result, glyphosate effectively kills annual broadleaf weeds and grasses that compete with crops by disrupting their growth processes while leaving non-target species unharmed.
  • What are the environmental implications of using glyphosate-resistant crops, and how do they affect agricultural practices?
    • The introduction of glyphosate-resistant crops has allowed farmers to apply glyphosate without harming their crops, simplifying weed management. However, this practice has led to increased herbicide usage and the emergence of glyphosate-resistant weed species, which can result in a cycle of dependency on more potent chemicals. Additionally, there are concerns about potential impacts on non-target organisms and overall biodiversity within ecosystems.
  • Evaluate the controversies surrounding glyphosate use in agriculture regarding its safety and regulatory status.
    • The controversies surrounding glyphosate stem from conflicting studies on its safety, particularly regarding its potential carcinogenic effects. The International Agency for Research on Cancer classified glyphosate as 'probably carcinogenic in humans' based on limited evidence from epidemiological studies. This classification has led to significant legal battles and calls for stricter regulations or bans in various regions. The debate highlights the need for continued research into glyphosate's long-term health effects and its role in sustainable agricultural practices.
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