Ototoxicity

Definition

Ototoxicity is the property of being toxic to the ear, specifically the cochlea or auditory nerve, and sometimes the vestibular system. It can result in temporary or permanent hearing loss and balance disorders.

5 Must Know Facts For Your Next Test

1. Loop diuretics like furosemide (Lasix) can cause ototoxicity, especially at high doses.
2. Ototoxicity from loop diuretics is usually reversible if detected early and the drug is discontinued.
3. Patients with renal impairment are at higher risk for ototoxicity when taking loop diuretics.
4. Symptoms of ototoxicity include tinnitus (ringing in the ears), hearing loss, and dizziness.
5. Monitoring for signs of ototoxicity is essential in patients receiving high doses or long-term therapy with loop diuretics.

Review Questions

• What class of drugs commonly associated with causing ototoxicity includes furosemide?
• List three symptoms that may indicate a patient is experiencing ototoxicity.
• Why are patients with renal impairment at higher risk for ototoxicity when taking loop diuretics?

Related terms

Nephrotoxicity:

Toxicity that results in damage to the kidneys.

Tinnitus:

A ringing or buzzing sound in one or both ears that may be caused by exposure to loud noise or ototoxic medications.

Vestibular System:

The system in the inner ear involved with maintaining balance and spatial orientation.