Nociceptors

Definition

Nociceptors are specialized sensory receptors that detect signals from damaged tissue or the threat of damage and transmit pain signals to the central nervous system. They play a crucial role in the body's ability to perceive pain.

5 Must Know Facts For Your Next Test

1. Nociceptors can be activated by mechanical, thermal, and chemical stimuli.
2. They are predominantly found in skin, joints, and some internal organs.
3. There are two main types: A-delta fibers for fast, sharp pain and C-fibers for slow, aching pain.
4. Nociceptors release neurotransmitters such as substance P and glutamate when activated.
5. Their activation triggers the pain pathway which includes transmission through the spinal cord to the brain.

Review Questions

• What types of stimuli can activate nociceptors?
• Where in the body are nociceptors primarily located?
• What neurotransmitters do nociceptors release when activated?

Related terms

Analgesics:

Drugs that relieve pain without causing loss of consciousness.

Hyperalgesia:

An increased sensitivity to pain due to changes in nociceptor function or number.

Neuropathic Pain:

Pain caused by damage or disease affecting the somatosensory nervous system.