Mast cells

Definition

Mast cells are a type of white blood cell that play a crucial role in the immune system by releasing histamine and other chemicals during inflammatory and allergic reactions. They are found in connective tissues throughout the body, particularly near blood vessels and nerves.

5 Must Know Facts For Your Next Test

1. Mast cells release histamine, which contributes to inflammation and allergic responses.
2. They contain granules rich in heparin, histamine, and other mediators.
3. Mast cells can be activated by allergens, physical injury, or microbial infections.
4. Mast cell stabilizers are drugs that prevent the release of inflammatory mediators from mast cells.
5. These cells play a significant role in conditions such as asthma, eczema, and anaphylaxis.

Review Questions

• What substances do mast cells release during an allergic reaction?
• How do mast cell stabilizers function in the context of pharmacology for nurses?
• In what types of tissues are mast cells most commonly found?

Related terms

Histamine:

A compound released by mast cells that causes vasodilation and increased permeability of blood vessels.

Leukotrienes:

Inflammatory chemicals released from leukocytes, including mast cells, that contribute to conditions like asthma.

Anti-inflammatory Drugs:

Medications designed to reduce inflammation by blocking certain pathways or substances involved in the inflammatory response.