Pharmacology for Nurses

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Fibrinolysis

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Pharmacology for Nurses

Definition

Fibrinolysis is the biological process that breaks down fibrin in blood clots. This mechanism is crucial to prevent excessive clot formation and maintain vascular health.

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5 Must Know Facts For Your Next Test

  1. Fibrinolysis involves the conversion of plasminogen to plasmin, which degrades fibrin.
  2. Tissue plasminogen activator (tPA) and urokinase are key enzymes that catalyze this process.
  3. Antifibrinolytic drugs inhibit fibrinolysis and are used to treat or prevent excessive bleeding.
  4. Plasminogen activator inhibitor-1 (PAI-1) regulates fibrinolysis by inhibiting tPA and urokinase.
  5. Impaired fibrinolysis can lead to conditions like thrombosis or embolism, while hyperfibrinolysis can cause hemorrhage.

Review Questions

  • What role does plasmin play in the process of fibrinolysis?
  • Name two key enzymes involved in activating fibrinolysis.
  • How do antifibrinolytic drugs affect the process of fibrinolysis?

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