Fibrinogen

Definition

Fibrinogen is a plasma protein that is essential for blood clotting. It is converted by thrombin into fibrin during the coagulation process.

5 Must Know Facts For Your Next Test

1. Fibrinogen levels are measured to assess bleeding disorders and liver function.
2. Normal fibrinogen levels in adults range from 200 to 400 mg/dL.
3. Low fibrinogen levels can lead to excessive bleeding, while high levels may increase the risk of thrombosis.
4. Fibrinogen is produced by the liver and released into the bloodstream.
5. Certain conditions like DIC (Disseminated Intravascular Coagulation) and liver disease can significantly alter fibrinogen levels.

Review Questions

• What role does fibrinogen play in the coagulation process?
• How do abnormal fibrinogen levels affect hemostasis?
• Why might a healthcare provider measure a patient's fibrinogen levels?

Related terms

Thrombin:

An enzyme that converts fibrinogen into fibrin during blood clotting.

Fibrin:

A fibrous protein formed from fibrinogen by thrombin, which forms the meshwork of a blood clot.

Hemostasis:

The process of stopping bleeding, which involves coagulation factors including fibrinogen.