Cinacalcet

Definition

Cinacalcet is a calcimimetic medication that decreases parathyroid hormone (PTH) levels by increasing the sensitivity of calcium-sensing receptors on the parathyroid gland. It is primarily used to treat secondary hyperparathyroidism in patients with chronic kidney disease on dialysis and hypercalcemia in patients with parathyroid carcinoma.

5 Must Know Facts For Your Next Test

1. Cinacalcet works by binding to calcium-sensing receptors on the parathyroid gland, enhancing their sensitivity to extracellular calcium.
2. It is commonly prescribed for secondary hyperparathyroidism in patients undergoing dialysis due to chronic kidney disease.
3. Cinacalcet is also used to manage hypercalcemia in patients with parathyroid carcinoma and primary hyperparathyroidism when surgery is not an option.
4. The medication can cause side effects such as nausea, vomiting, and hypocalcemia (low blood calcium levels).
5. Monitoring of serum calcium and PTH levels is essential during Cinacalcet therapy to avoid complications.

Review Questions

• How does Cinacalcet affect the calcium-sensing receptors on the parathyroid gland?
• For which conditions is Cinacalcet primarily prescribed?
• What are some common side effects associated with Cinacalcet?

Related terms

Parathyroid Hormone (PTH): A hormone secreted by the parathyroid glands that regulates serum calcium levels.

Secondary Hyperparathyroidism: A condition characterized by excessive secretion of PTH due to chronic kidney disease.

Hypercalcemia:

An abnormally high level of calcium in the blood, which can be associated with various diseases, including parathyroid carcinoma.