Calcipotriene

Definition

Calcipotriene is a synthetic derivative of vitamin D3 used topically to treat plaque psoriasis. It helps regulate the growth and differentiation of skin cells.

5 Must Know Facts For Your Next Test

1. Calcipotriene is primarily used to manage plaque psoriasis by reducing scaling and thickness of psoriatic lesions.
2. It works by binding to vitamin D receptors in the skin, leading to decreased cell proliferation and increased cell differentiation.
3. Common side effects include skin irritation, burning, itching, and redness at the site of application.
4. It is often combined with corticosteroids like betamethasone for enhanced efficacy in treating psoriasis.
5. Patients should avoid excessive sun exposure while using calcipotriene due to potential photosensitivity.

Review Questions

• What is the primary use of calcipotriene in dermatologic disorders?
• How does calcipotriene exert its therapeutic effects on psoriatic lesions?
• What are common side effects associated with topical calcipotriene?

Related terms

Betamethasone:

A potent corticosteroid often combined with calcipotriene to treat plaque psoriasis.

Topical Corticosteroids:

Medications applied to the skin that reduce inflammation and immune responses.

Plaque Psoriasis:

A chronic autoimmune condition characterized by red, scaly patches on the skin.