Atherosclerosis

Definition

Atherosclerosis is a condition characterized by the buildup of fatty deposits, cholesterol, and other substances in the arterial walls, leading to narrowed and hardened arteries. This can impede blood flow and increase the risk of cardiovascular events.

5 Must Know Facts For Your Next Test

1. Atherosclerosis primarily involves the accumulation of low-density lipoproteins (LDL) in arterial walls.
2. High levels of LDL cholesterol are strongly associated with an increased risk of atherosclerosis.
3. Statins are commonly prescribed lipid-lowering drugs that help reduce LDL cholesterol levels to manage or prevent atherosclerosis.
4. Apolipoprotein B (ApoB) is a key protein in LDL particles and plays a significant role in the development of atherosclerotic plaques.
5. Lifestyle changes, such as diet and exercise, along with pharmacological interventions are critical in managing and preventing atherosclerosis.

Review Questions

• What role do low-density lipoproteins (LDL) play in the development of atherosclerosis?
• How do statins help manage or prevent atherosclerosis?
• Why is Apolipoprotein B (ApoB) significant in the context of atherosclerosis?

Related terms

Low-Density Lipoprotein (LDL): Often referred to as 'bad' cholesterol, it contributes to plaque buildup in arteries.

Statins:

A class of drugs that lower cholesterol levels by inhibiting an enzyme involved in its production.

Apolipoprotein B (ApoB): A primary protein component of LDL particles crucial for their transport and binding to cell receptors.