Tau protein

Definition

Tau protein is a microtubule-associated protein primarily found in neurons of the central nervous system. It plays a crucial role in stabilizing microtubules, which are essential for maintaining cell structure and function.

5 Must Know Facts For Your Next Test

1. Tau protein abnormalities are implicated in various neurodegenerative diseases, including Alzheimer's disease.
2. Hyperphosphorylation of tau proteins leads to their aggregation into neurofibrillary tangles, disrupting neuronal function.
3. Dietary factors such as omega-3 fatty acids and antioxidants may influence tau pathology and offer neuroprotective benefits.
4. Inflammation and oxidative stress are key mechanisms through which tau protein dysfunction can occur.
5. Research suggests that maintaining proper nutritional status could potentially slow the progression of tau-related neurodegenerative conditions.

Review Questions

• What role does hyperphosphorylation play in tau protein dysfunction?
• Which dietary components are believed to influence tau pathology?
• How do inflammation and oxidative stress contribute to tau-related neurological issues?

Related terms

Alzheimer's Disease: A progressive neurodegenerative disorder characterized by the accumulation of amyloid plaques and tau tangles.

Microtubules: Cylindrical structures within cells that provide structural support and facilitate intracellular transport.

Neurofibrillary Tangles: Aggregates of hyperphosphorylated tau protein found inside neurons, commonly associated with Alzheimer's disease.