Bisphosphonates are a class of drugs that prevent the loss of bone density by inhibiting osteoclast-mediated bone resorption. They are commonly used to treat osteoporosis and other conditions that cause bone fragility.
congrats on reading the definition of bisphosphonates. now let's actually learn it.
They are often prescribed for postmenopausal women to reduce the risk of fractures.
Bisphosphonates can be administered orally or intravenously, depending on the specific medication and patient needs.
These drugs may cause gastrointestinal side effects like esophagitis, which is why patients are advised to remain upright for at least 30 minutes after taking them.
They have been shown to improve bone mineral density (BMD) and reduce the incidence of spine and hip fractures in high-risk populations.
Long-term use of bisphosphonates has been associated with rare but serious side effects such as osteonecrosis of the jaw and atypical femur fractures.
Review Questions
What is the primary mechanism by which bisphosphonates work to prevent bone loss?
Why might a patient be instructed to stay upright for 30 minutes after taking an oral bisphosphonate?
What are some potential serious side effects associated with long-term bisphosphonate use?
Cells that break down bone tissue, playing a critical role in bone remodeling and resorption.
Bone Mineral Density (BMD): A measure of the amount of minerals (such as calcium) in a defined area of bone, used as an indicator of bone strength and health.