Nuclear lamina

Definition

The nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells that provides structural support and regulates important cellular events such as DNA replication and cell division.

5 Must Know Facts For Your Next Test

1. The nuclear lamina is composed mainly of intermediate filaments called lamins.
2. It plays a critical role in maintaining the shape and stability of the nucleus.
3. Mutations in lamin genes can lead to a variety of genetic diseases known as laminopathies.
4. The nuclear lamina interacts with chromatin, influencing gene expression and chromosome organization.
5. It disassembles during mitosis to allow for chromosomal segregation and reassembles afterwards.

Review Questions

• What primary components make up the nuclear lamina?
• How does the nuclear lamina contribute to the structural integrity of the nucleus?
• What are some potential consequences of mutations in lamin genes?

Related terms

Lamins: Proteins that form a meshwork underlying the inner nuclear membrane, essential for nuclear stability.

Nuclear Envelope:

A double membrane structure that encloses the nucleus, consisting of an outer and inner membrane.

Chromatin:

The complex of DNA and protein found in eukaryotic cells, which packages DNA into a more compact, dense shape.