Mebendazole

Definition

Mebendazole is a broad-spectrum anthelmintic drug used to treat parasitic worm infections, particularly those affecting the gastrointestinal tract. It works by inhibiting the synthesis of microtubules, leading to impaired glucose uptake in helminths.

5 Must Know Facts For Your Next Test

1. Mebendazole is effective against multiple types of intestinal worms, including roundworms, hookworms, and whipworms.
2. It disrupts the microtubule formation in parasites, which is essential for their nutrient absorption and survival.
3. The drug is typically administered orally and has minimal systemic absorption, making it largely confined to the gut where it exerts its effects.
4. Common side effects include abdominal pain, diarrhea, and headache.
5. Mebendazole should be avoided during pregnancy due to potential teratogenic effects.

Review Questions

• What types of parasitic worms is mebendazole effective against?
• How does mebendazole disrupt the metabolic functions of helminths?
• Why should mebendazole be used with caution in pregnant individuals?

Related terms

Albendazole:

An anthelmintic similar to mebendazole but with broader systemic absorption.

Helminthiasis:

An infection caused by parasitic worms.

Anthelmintic Drugs:

Medications used to treat infections by parasitic worms.