Fibrin

Definition

Fibrin is a fibrous protein involved in blood clotting, forming a mesh that impedes the flow of blood. It is generated from fibrinogen by the action of thrombin during the coagulation cascade.

5 Must Know Facts For Your Next Test

1. Fibrin plays a crucial role in the final stage of blood coagulation, forming a stable clot.
2. It is formed from its precursor, fibrinogen, which is converted by the enzyme thrombin.
3. Bacterial pathogens can produce fibrinolysin to dissolve fibrin clots and spread infection.
4. The formation of fibrin can be part of the body's defense mechanism to localize infections and limit bacterial spread.
5. Certain virulence factors target or manipulate the host's fibrin production to enhance pathogenicity.

Review Questions

• What enzyme converts fibrinogen into fibrin?
• How do bacterial pathogens utilize fibrinolysin concerning fibrin?
• Why is the formation of a fibrin clot important in microbial infections?

Related terms

Thrombin: An enzyme that converts fibrinogen into fibrin during blood coagulation.

Fibrinolysin: An enzyme produced by some bacteria that dissolves fibrin clots.

Coagulation Cascade: A series of steps involving multiple enzymes and cofactors leading to blood clot formation.