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🦠microbiology review

key term - Envelope

Citation:

Definition

The envelope is a protective, lipid-containing structure that surrounds the capsid of certain viruses, including influenza, HIV, and coronaviruses. It is derived from the host cell's membrane and plays a crucial role in the virus's ability to infect and spread to new host cells.

5 Must Know Facts For Your Next Test

  1. The viral envelope is composed of a lipid bilayer and various glycoproteins that play a crucial role in the virus's ability to infect host cells.
  2. Glycoproteins embedded in the envelope, such as hemagglutinin (HA) and neuraminidase (NA) in influenza viruses, facilitate attachment to and entry into host cells.
  3. The envelope protects the viral capsid and genetic material, shielding them from the host's immune defenses and environmental factors.
  4. Enveloped viruses are generally more fragile and sensitive to environmental conditions, such as desiccation and disinfectants, compared to non-enveloped viruses.
  5. The composition and structure of the viral envelope can be targeted by antiviral drugs and vaccines, making it a crucial target for therapeutic interventions.

Review Questions

  • Describe the structure and function of the viral envelope.
    • The viral envelope is a lipid-containing structure that surrounds the capsid of certain viruses. It is derived from the host cell's membrane and is composed of a lipid bilayer and various glycoproteins. The glycoproteins embedded in the envelope, such as hemagglutinin (HA) and neuraminidase (NA) in influenza viruses, play a crucial role in the virus's ability to attach to and enter host cells. The envelope protects the viral capsid and genetic material, shielding them from the host's immune defenses and environmental factors. The composition and structure of the viral envelope can be targeted by antiviral drugs and vaccines, making it a crucial target for therapeutic interventions.
  • Explain the importance of the viral envelope in the context of viral infection and transmission.
    • The viral envelope is essential for the virus's ability to infect and spread to new host cells. The glycoproteins embedded in the envelope facilitate the attachment and entry of the virus into host cells, allowing the viral genetic material to be delivered and replicated. Additionally, the envelope protects the viral capsid and genetic material from the host's immune defenses and environmental factors, enhancing the virus's stability and increasing its chances of successful transmission. The composition and structure of the viral envelope are crucial targets for the development of antiviral drugs and vaccines, as disrupting the envelope can effectively prevent or mitigate viral infections.
  • Analyze the role of the viral envelope in the context of viral evolution and adaptation.
    • The viral envelope plays a critical role in the evolutionary adaptability of viruses. The glycoproteins embedded in the envelope are subject to genetic mutations, which can lead to changes in their structure and function. These changes can allow the virus to evade host immune responses, expand its host range, or increase its infectivity and transmission. For example, the rapid evolution of the spike protein in SARS-CoV-2, a key component of the viral envelope, has enabled the virus to adapt to new host cell receptors and become more transmissible. Additionally, the lipid composition of the envelope can also influence the virus's stability and environmental resistance, contributing to its ability to persist and spread. Understanding the evolutionary dynamics of the viral envelope is crucial for developing effective countermeasures against emerging and evolving viral threats.

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