Echinocandins

Definition

Echinocandins are a class of antifungal drugs that inhibit the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall. They are particularly effective against Candida and Aspergillus species.

5 Must Know Facts For Your Next Test

1. Echinocandins target the enzyme glucan synthase, disrupting fungal cell wall integrity.
2. They are often used to treat invasive candidiasis and aspergillosis.
3. Echinocandins are typically administered intravenously due to poor oral bioavailability.
4. Common examples include caspofungin, micafungin, and anidulafungin.
5. They have a favorable safety profile with fewer side effects compared to other antifungal agents.

Review Questions

• What is the primary mechanism of action for echinocandins?
• Which types of fungal infections are echinocandins most effective against?
• Why are echinocandins administered intravenously rather than orally?

Related terms

Glucan Synthase: An enzyme targeted by echinocandins that synthesizes β-(1,3)-D-glucan in fungal cell walls.

Candida:

A genus of yeast commonly responsible for infections treated by echinocandins.

Aspergillus:

A genus of mold fungi that can cause serious infections in immunocompromised individuals.