Collagen

Definition

Collagen is a structural protein found in the extracellular matrix of various connective tissues in animals. It provides strength and support to tissues including skin, bones, and tendons.

5 Must Know Facts For Your Next Test

1. Collagen is the most abundant protein in mammals, making up about 25-35% of the whole-body protein content.
2. It consists of three polypeptide chains wound together in a triple helix structure.
3. There are at least 28 different types of collagen identified, with Type I being the most common.
4. Collagen synthesis occurs within fibroblasts and involves several post-translational modifications.
5. Collagen degradation is mediated by specific enzymes called matrix metalloproteinases (MMPs).

Review Questions

• What is the primary structural feature of collagen?
• Which cell type is primarily responsible for collagen synthesis?
• Name the enzyme group involved in collagen degradation.

Related terms

Extracellular Matrix: A complex network of proteins and carbohydrates that provide structural and biochemical support to surrounding cells.

Fibroblast: A type of cell that synthesizes extracellular matrix components, including collagen.

Matrix Metalloproteinases (MMPs): A group of enzymes that degrade various components of the extracellular matrix, including collagen.