Bacteriostatic

Definition

Bacteriostatic agents inhibit the growth and reproduction of bacteria without killing them. They rely on the immune system to eliminate the inhibited bacteria.

5 Must Know Facts For Your Next Test

1. Bacteriostatic agents work by interfering with bacterial protein production, DNA replication, or other aspects of cellular metabolism.
2. Common examples of bacteriostatic antibiotics include tetracyclines, macrolides, and sulfonamides.
3. Bacteriostatic drugs are often contrasted with bactericidal drugs, which kill bacteria directly.
4. Effectiveness of a bacteriostatic agent can depend on the concentration used and the duration of exposure.
5. Bacteriostatic agents are particularly useful in situations where bacterial endotoxin release could worsen a patient's condition.

Review Questions

• What is the primary mechanism by which bacteriostatic agents control bacterial growth?
• Name at least two examples of bacteriostatic antibiotics.
• How do bacteriostatic agents differ from bactericidal agents?

Related terms

Bactericidal:

Agents that kill bacteria outright.

Antibiotics:

Substances that can destroy or inhibit the growth of microorganisms.

Minimum Inhibitory Concentration (MIC):

The lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation.