Desmosomes

Definition

Desmosomes are specialized structures within the plasma membrane that function to anchor adjacent cells together. They provide mechanical strength to tissues by linking the cytoskeletons of neighboring cells.

5 Must Know Facts For Your Next Test

1. Desmosomes are composed of cadherin proteins which mediate cell-cell adhesion.
2. They are most commonly found in tissues subjected to significant mechanical stress, such as the skin and heart muscle.
3. Desmosomes connect to intermediate filaments within the cell, aiding in cellular structural integrity.
4. Mutations in desmosomal proteins can lead to diseases like Pemphigus vulgaris, which causes skin blistering.
5. Desmosomes work in conjunction with other cell junctions like tight junctions and gap junctions to maintain tissue structure.

Review Questions

• What role do desmosomes play in maintaining tissue integrity?
• Which types of proteins are primarily involved in forming desmosomes?
• In what types of tissues are desmosomes especially important, and why?

Related terms

Tight Junctions: Tight junctions create a seal between adjacent cells to prevent the passage of molecules through intercellular spaces.

Gap Junctions: Gap junctions allow direct communication between adjacent cells through channels known as connexons.

Intermediate Filaments: Intermediate filaments are part of the cytoskeleton that provide mechanical support for the cell's shape and structure.