The extracellular matrix (ECM) is a complex network of proteins and polysaccharides secreted by cells into their external environment. It provides structural and biochemical support to surrounding cells in tissues.
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The main components of the ECM are collagen, elastin, fibronectin, laminin, and proteoglycans.
ECM plays a critical role in cell adhesion, communication, and differentiation.
Matrix metalloproteinases (MMPs) are enzymes that can degrade ECM components during tissue remodeling and repair.
Integrins are transmembrane receptors that facilitate cell-ECM adhesion.
The ECM composition varies significantly between different types of tissues.
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Related terms
Collagen: A major structural protein in the ECM that provides tensile strength.