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Dependence refers to a state in which an individual relies on a substance or behavior to function normally, and experiences withdrawal symptoms when the substance or behavior is removed. It involves physical and psychological reliance.
Tolerance refers to the body's reduced response to a substance over time, requiring higher doses for the same effect.
Withdrawal is the set of physical and psychological symptoms that occur when a person stops using or engaging in something they are dependent on.
Substance use disorder refers to a condition characterized by compulsive drug seeking and use, despite negative consequences.