Perforin

Definition

Perforin is a protein produced by certain immune cells, such as natural killer cells and cytotoxic T lymphocytes, that forms pores in the membranes of targeted cells leading to cell death. It plays a critical role in the body's innate immune response by helping to eliminate infected or cancerous cells.

Related terms

Natural Killer Cells:

A type of white blood cell that can kill tumor cells and virus-infected cells without prior activation.

Cytotoxic T Lymphocytes: Immune cells that can directly attack and kill infected or cancerous cells by recognizing specific antigens presented on their surface.

Innate Immune Response: The first line of defense against pathogens that includes physical barriers, chemical barriers, and immune cells that are always ready to fight infections