💀Anatomy and Physiology I Unit 17 – The Endocrine System

Overview of the Endocrine System

• Consists of glands that secrete hormones directly into the bloodstream
• Regulates various bodily functions (growth, metabolism, reproduction)
• Works in conjunction with the nervous system to maintain homeostasis
• Includes major glands (pituitary, thyroid, parathyroid, adrenal, pancreas)
  • Also includes smaller glands (pineal, thymus, ovaries, testes)
• Hormones act as chemical messengers targeting specific cells or organs
• Endocrine glands are ductless, unlike exocrine glands (sweat glands, salivary glands)
• Plays a crucial role in development, stress response, and overall health

Major Endocrine Glands and Their Functions

• Pituitary gland: "Master gland" located at the base of the brain
  • Anterior pituitary secretes hormones (growth hormone, TSH, ACTH, FSH, LH, prolactin)
  • Posterior pituitary releases hormones produced by the hypothalamus (ADH, oxytocin)
• Thyroid gland: Located in the neck, produces thyroid hormones (T3 and T4)
  • Regulates metabolism, growth, and development
• Parathyroid glands: Four small glands located behind the thyroid
  • Secrete parathyroid hormone (PTH) to regulate calcium homeostasis
• Adrenal glands: Located above the kidneys, consist of the cortex and medulla
  • Adrenal cortex produces glucocorticoids (cortisol), mineralocorticoids (aldosterone), and androgens
  • Adrenal medulla secretes catecholamines (epinephrine and norepinephrine) in response to stress
• Pancreas: Both an endocrine and exocrine gland
  • Endocrine portion (islets of Langerhans) secretes insulin and glucagon to regulate blood sugar
• Gonads (ovaries and testes): Produce sex hormones (estrogen, progesterone, testosterone)
  • Regulate reproductive function and secondary sexual characteristics

Hormones: Types and Mechanisms

• Hormones are classified based on their chemical structure
  • Peptide hormones: Composed of amino acids (insulin, ADH, oxytocin)
  • Steroid hormones: Derived from cholesterol (cortisol, aldosterone, sex hormones)
  • Amine hormones: Derived from amino acids (thyroid hormones, catecholamines)
• Hormones bind to specific receptors on target cells
  • Receptor-hormone complex initiates cellular responses
• Peptide and amine hormones typically bind to surface receptors
  • Activate second messenger systems (cAMP, IP3) to elicit cellular responses
• Steroid hormones and thyroid hormones pass through the cell membrane
  • Bind to intracellular receptors and directly influence gene transcription
• Hormone action can be modulated by factors (hormone concentration, receptor sensitivity, target cell responsiveness)

Hormone Regulation and Feedback Loops

• Endocrine system maintains homeostasis through feedback loops
  • Negative feedback: Hormone levels are regulated to maintain a set point
    • Example: High blood glucose stimulates insulin release, which lowers blood glucose
  • Positive feedback: Hormone action is amplified, leading to a rapid response
    • Example: Oxytocin release during childbirth stimulates uterine contractions, further increasing oxytocin release
• Hypothalamus plays a central role in hormone regulation
  • Releases releasing hormones (CRH, TRH, GnRH) to stimulate anterior pituitary
  • Responds to feedback from target glands and hormones
• Pituitary gland acts as a relay between the hypothalamus and target glands
  • Anterior pituitary hormones (TSH, ACTH, FSH, LH) stimulate target glands
  • Target glands secrete hormones that provide feedback to the hypothalamus and pituitary
• Feedback loops involve multiple levels of control
  • Long loop: Hypothalamus, pituitary, and target gland
  • Short loop: Hypothalamus and pituitary
  • Ultra-short loop: Within the hypothalamus itself

Endocrine System Disorders

• Hypersecretion: Excessive hormone production
  • Example: Cushing's syndrome (excess cortisol)
    • Symptoms: Weight gain, moon face, buffalo hump, skin changes, hypertension
  • Example: Hyperthyroidism (excess thyroid hormones)
    • Symptoms: Weight loss, heat intolerance, tachycardia, anxiety
• Hyposecretion: Insufficient hormone production
  • Example: Addison's disease (deficient cortisol and aldosterone)
    • Symptoms: Fatigue, weight loss, hypotension, skin pigmentation
  • Example: Hypothyroidism (deficient thyroid hormones)
    • Symptoms: Weight gain, cold intolerance, bradycardia, dry skin
• Hormone resistance: Target cells do not respond properly to hormones
  • Example: Type 2 diabetes mellitus (insulin resistance)
    • Leads to hyperglycemia and associated complications
• Endocrine tumors: Abnormal growth of endocrine glands
  • Can cause hypersecretion or hyposecretion of hormones
  • Example: Pituitary adenomas, thyroid nodules, adrenal tumors

Clinical Applications and Diagnostics

• Blood tests: Measure hormone levels to diagnose endocrine disorders
  • Examples: TSH, free T4, cortisol, ACTH, insulin, glucose
• Stimulation and suppression tests: Assess gland function and feedback loops
  • Example: Dexamethasone suppression test for Cushing's syndrome
  • Example: TSH stimulation test for hypothyroidism
• Imaging studies: Visualize endocrine glands and tumors
  • Ultrasound: Thyroid nodules, ovarian cysts
  • CT and MRI: Pituitary tumors, adrenal masses
• Hormone replacement therapy: Treat hyposecretion disorders
  • Levothyroxine for hypothyroidism
  • Insulin for type 1 diabetes mellitus
  • Glucocorticoids for adrenal insufficiency
• Medications: Modulate hormone secretion or action
  • Antithyroid drugs (methimazole, propylthiouracil) for hyperthyroidism
  • Somatostatin analogs (octreotide) for acromegaly
  • Aromatase inhibitors (anastrozole) for hormone-sensitive breast cancer

Key Takeaways and Study Tips

• The endocrine system consists of glands that secrete hormones to regulate bodily functions
• Major endocrine glands include the pituitary, thyroid, parathyroid, adrenal, and pancreas
• Hormones are classified as peptide, steroid, or amine based on their chemical structure
• Hormones bind to specific receptors on target cells to elicit cellular responses
• Feedback loops (negative and positive) maintain homeostasis and regulate hormone levels
• Endocrine disorders can result from hypersecretion, hyposecretion, or hormone resistance
• Clinical applications involve blood tests, imaging studies, and hormone replacement therapy
• When studying, focus on understanding the functions and regulation of each endocrine gland
  • Create flowcharts or diagrams to visualize feedback loops and hormone actions
  • Use mnemonics to remember hormone names and functions (e.g., FLAT PiG for anterior pituitary hormones)
  • Practice applying your knowledge to clinical scenarios and case studies